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KMID : 0368820160550030209
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Journal of the Korean Neuropsychiatr Association
2016 Volume.55 No. 3 p.209 ~ p.214
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Delay in Normalization of Disrupted Sleep-Wake Cycle in Mice as a Bipolar Disorder-Prone Animal Model (Bipolar Disorder-Prone Animal Model)
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Kim Soo-Yeon
Moon Eun-Soo
Jeong Hee-Jeong
Lee Young-Min
Lee Byung-Dae
Park Je-Min
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Abstract
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Objectives: This study was designed to test the hypothesis that delayed recovery from disrupted circadian rhythm is associated with both manic and depressive episodes in bipolar disorder.
Methods: Twenty-two male mice (age of five weeks, weight 28?30 gm) underwent three days of light-dark cycle disruption and 10 days of recovery phase. Sleep and wake state were checked every five minutes during the entire experimental period. After recovery phase, quinpirole (0.5 mg/kg, s.c.) was injected into the mice and open field locomotor activities were checked. Five days after the open field test, immobility time during the last 4 min in 6 min of forced swimming test was measured. Animals which recovered sleep-wake cycle within six days after light-dark cycle disruption were assigned to the early recovery group (n=14), and those that failed to recover in six days were assigned to the delayed recovery group (n=8). The locomotor activities and the immobility times of the two groups were compared by Mann-Whiney U test at two-tailed significance level of 0.05.
Results: The locomotor activities of the delayed recovery group were higher (mean rank=16.19) than those of the early recovery group (mean rank=8.82, U=18.5, p=0.008). The immobility times did not differ by recovery time (U=32.0 p=0.110).
Conclusion: The results suggest that delayed recovery from circadian rhythm disruption raises the risk of manic symptoms rather than depressive symptoms.
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KEYWORD
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Bipolar disorder, Circadian rhythm, Quinpirole, Open field test, Forced swimming test
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